Impaired Angiotensin Conversion and Bradykinin Clearance in Experimental Canine Pulmonary Emphysema
نویسندگان
چکیده
منابع مشابه
Impaired angiotensin conversion and bradykinin clearance in experimental canine pulmonary emphysema.
Chronic hypoxic lung diseases are associated with abnormal blood pressure regulation. Because the lung is the principal site of angiotensin conversion and because hypoxia decreases converting enzyme activity, we examined whether angiotensin converting enzyme activity was impaired in lung disease. 12 dogs received a 6 wk course of aerosolized and intratracheal papain that produced moderate panlo...
متن کاملHyperreactivity to bradykinin and alterations in angiotensin I conversion and bradykinin inactivation in renal hypertensive rats.
Low doses (1-10 ng) of angiotensin I (AI) injected Intravenously into conscious rats produced greater pressure changes than when injected intraaortically. This finding again indicates the importance of the pulmonary circulation in the conversion of AI to angiotensin II (All). At high doses of hormone (30 ng, which produces pressure rises of 40-50 mm Hg) the Intravenous and intraarterial respons...
متن کاملHyperreactivity to Bradykinin and Alterations in Angiotensin I Conversion and Bradykinin Inactivation in Renal Hypertensive Rats
Low doses (1-10 ng) of angiotensin I (AI) injected Intravenously into conscious rats produced greater pressure changes than when injected intraaortically. This finding again indicates the importance of the pulmonary circulation in the conversion of AI to angiotensin II (All). At high doses of hormone (30 ng, which produces pressure rises of 40-50 mm Hg) the Intravenous and intraarterial respons...
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1. A specific method is described for the measurement of angiotensin I converting enzyme activity in plasma with 125 I-labelled angiotensin I used as substrate. 2. Converting enzyme activity in plasma from fifteen normal subjects, eleven patients with sarcoidosis, twelve patients with chronic obstructive pulmonary disease and three patients with shock lung was assayed by this technique. 3. Pati...
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UNLABELLED The aim of this study was to evaluate impaired lung uptake of (123)I-metaiodobenzylguanidine ((123)I-MIBG) on SPECT, compared with perfusion SPECT and morphologic CT, in patients with pulmonary emphysema (PE). METHODS (123)I-MIBG SPECT was performed at 15 min and 4 h after intravenous injection of (123)I-MIBG in 36 PE patients with a history of smoking and variable-extent low-atten...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1981
ISSN: 0021-9738
DOI: 10.1172/jci110014